Table 2.
Lymphocytes and T-cell subsets in patients (DM, NDM) and controls; p value calculated for differences between three groups (ANOVA or Kruskal–Wallis H test), and between DM and NDM (Mann–Whitney U test). WCC, white-cell count; NLR, neutrophil/lymphocyte count; IRP, immunological risk profile.
| DM | NDM | Controls | p | p (DM vs. NDM) | |
|---|---|---|---|---|---|
| N | 28 | 28 | 25 | ||
| WCC (K/μL) | 7600 ± 2076 | 7399 ± 2365 | 6726 ± 1314 | NS | NS |
| Neutrophils (K/μL) | 5927 ± 1729 | 5029 ± 1985 | 4061 ± 1444 | 0.02 | NS |
| Neutrophils (%) | 72 ± 10 | 68 ± 7.5 | 59 ± 13 | 0.008 | NS |
| Lymphocytes (K/μL) | 1212 ± 564 | 1435 ± 596 | 2198 ± 556 | 0.0001 | NS |
| Lymphocytes (%) | 16.5 ± 9.4 | 19.5 ± 6 | 33.6 ± 9.4 | 0.0001 | NS |
| NLR | 6 ± 4.9 | 3.9 ± 2 | 2 ± 1.1 | 0.0001 | NS |
| T-cell subtypes | |||||
| CD3+CD4+ cells | 622(150–1412) | 693.9(224–1579) | 943(584–1876) | 0.001 | NS |
| CD3+CD4+ cells (%) | 43(30–71) | 48.7(27–63) | 49.6(36–66) | NS | NS |
| CD3+CD8+ cells | 235(135–600) | 352(102–149) | 406(263–775) | NS | NS |
| CD3+CD8+ cells (%) | 23(11–44) | 23(11–47) | 22(9–33) | NS | NS |
| CD4+/CD8+ | 1.6(0.7–4.8) | 1.9(0.7–4.3) | 2.3(1–7) | NS | NS |
| CD28null cells | 206.8(61–500) | 162.5(12.6–1209) | 155(26–430) | NS | NS |
| CD28null (%) | 21.3(4.4–34) | 14.6(1–50) | 7.2(1–17) | 0.005 | 0.02 |
| CD4+CD28null | 34.7(14–279) | 20.9(0–550) | 32(0.9–76) | NS | NS |
| CD4+CD28null (%) | 11.5(1.5–24) | 4.1(0–42.3) | 2.6(0.1–7.8) | 0.006 | 0.02 |
| CD8+CD28null | 132(47–400) | 114(12–735) | 116(25–391) | NS | NS |
| CD8+CD28null (%) | 61.3(24–76) | 43(5.7–85) | 39(7.8–57) | 0.008 | 0.04 |
| Natural killer cells | 141(56–460) | 174.6(0–617) | 258(119–1060) | 0.01 | NS |
| Naural killer cells (%) | 15.3(7.7–31) | 14.6(0–32.5) | 10.9(4.7–40) | NS | NS |
| Treg cells | 33.7(12–102) | 34.7(9.9–130) | 66.3(31–119) | 0.001 | NS |
| Treg cells (%) | 3.1(1.1–6.7) | 2.8(0.62–8.5) | 2.9(1.6–5.7) | NS | NS |
| IRP | 3(1–4) | 3(1–4) | 2(0–4) | 0.006 | NS |