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. 2021 Mar 16;9(3):333. doi: 10.3390/healthcare9030333

Table 1.

Current Recommendations for Equianalgesic Dosing of Opioids Commonly Encountered in Perioperative Settings.

Drug Equianalgesic Doses (mg)
IV/IM/SC 1 Dose PO/SL Dose
Oxycodone 2 10 20
Hydrocodone 3 N/A 25
Hydromorphone 4 2 5
Morphine 3 10 25
Fentanyl 0.15 N/A
Oxymorphone 1 10
Tapentadol N/A 100
Tramadol 2 100 120

1 The IM route of administration is not recommended. 2 IV formulation not available in the U.S. at the time of this writing. 3 Oral equianalgesic dose equivalent of 30 mg has been used and is also reasonable, given variations in bioavailability between morphine/hydrocodone and oxycodone (equianalgesic ratio ranges from 1:1 to 2:1 morphine:oxycodone based on individual patient absorption). 4 Previous resources have used a 1:5 ratio for parenteral:oral hydromorphone, but newer data suggest a ratio 1:2.5 is more appropriate. IM = intramuscular, IV = intravenous, mg = milligrams, N/A = not applicable, PO = oral, SC = subcutaneous, SL = sublingual. Adapted from Demystifying Opioid Conversion Calculations: A Guide for Effective Dosing, 2nd Edition, 2019 [71].