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. 2021 Mar 15;9(3):301. doi: 10.3390/biomedicines9030301

Figure 5.

Figure 5

Homology modeled complex structures for A2AAR-Gαs and AVPR2-Gαs systems. (A) Side view and (B) bottom view of A2AAR complexed with the Ras domain of Gαs. For A2AAR, cyan: TM6 at inactive state; blue: TM6 at active state. For Ras-Gαs, α5-helix: light red. In the inactive state of A2AAR, the TM6 may have steric repulsion with α5-helix to inhibit Gαs binding. (C) Side view and (D) bottom view of AVPR2 complexed with the Ras domain of Gαs. For AVPR2, cyan: initial time; blue: 1500 ns; green: AVPR2-ΔV279. For Ras-Gαs, α5-helix: light red. α5-helix of Gαs-protein may have strong steric repulsion with TM6 of the inactive AVPR2-ΔV279.