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. 2021 Mar 12;10(3):439. doi: 10.3390/antiox10030439

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical analysis of leukocyte common antigen (LCA, CD45) in the treatment groups. (A) Radar graph indicating the % IEL infiltration in a selected area of 100 cells; (B) in the uninjured group, smooth gastric mucosa showed a normal morphology and presence of a lower number of intraepithelial lymphocytes (fewer brown stains) with no infiltration (×100); (C) the injured group showed gastric mucosa with a large number of intraepithelial lymphocytes (more browning) and more infiltration (×100); (D) LPZ (30 mg/kg of lansoprazole) showed little infiltration of lymphocytes into the gastric epithelial layer (×100), (E) PUE-250 (250 mg/kg of PUE), and (F) PUE-500 (500 mg/kg of PUE) groups with mild intraepithelial leukocytes (×100).