Figure 4.
Reagents, solvents, and conditions: (a) 4-aminophenol, BrettPhos, Pd(dba3)2, NaOt-Bu, 90 °C, 12 h; (b) (±)-epichlorohydrin, MeCN, K2CO3, 80 °C, 16 h; (c) Me2NH × HCl, MeOH, 70 °C, 24 h.
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