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Potencies of compounds ZVS-08, 1 and 8 against KV10.1 and hERG.
| Compound ID | IC50 Kv10.1 (μM) | IC50 hERG (μM) |
|---|---|---|
| ZVS-08 | 3.70 µM (95% CI: 2.08 µM to 6.47 µM) | 0.194 µM (95% CI: 0.047 µM to 0.761 µM) |
| 1 | 0.740 µM (95% CI: 490 nM to 1.17 µM) | 0.207 µM (95% CI: 0.113 µM to 0.395 µM) |
| 8 | 1.01 µM (95% CI: 796 nM to 1.30 µM | 0.156 µM (95% CI: 0.070 µM to 0.373 µM) |
