Figure 1.

Schematic representation of de novo lipogenesis in chicken hepatocyte and its regulation at the transcriptional and post-transcriptional level. Red, orange, and green lines indicated the targets of various miRNAs, sterol response element-binding protein (SREBP1) as a transcription factor, and hormones in the chicken hepatocyte, respectively. PK, pyruvate kinase enzyme; TCA, tricarboxylic acid cycle; ACLY, ATP-citrate lyase; ACC, acetyl-CoA carboxylase; MD, malate dehydrogenase; NADPH, nicotinamide adenine dinucleotide phosphate; ME, malic enzyme; FASN, fatty acid synthase; ELOVL6, ELOVL fatty acid elongase 6; SCD, stearoyl-CoA desaturase; FADS, fatty acid desaturase; FA-CoA, fatty acid-acyl-CoA; ACSL, long-chain acyl-CoA synthetases; G3P, glycerol-3-phosphate; GPAT, glycerophosphate acyltransferase; AGPAT, acylglycerophosphate acyltransferase; LPIN, lipid phosphate phosphohydrolase; DGAT, diacylglycerol acyltransferase; MTTP, microsomal triglyceride transfer protein; VLDL, very-low-density lipoprotein; SFA, saturated fatty acid; USFA, unsaturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids; FFA, free fatty acids.