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. 2021 Mar 13;12(3):414. doi: 10.3390/genes12030414

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differentially expressed miRNA through chicken intramuscular preadipocyte differentiation in the breast muscle between juvenile and late-laying hen. Overexpression of gga-miR-140-5p reduced the expression of retinoid X receptor γ (RXRG) while upregulated the expression of adipogenic markers, including the peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid-binding protein 4 (FABP4); promoting intramuscular preadipocyte differentiation and IMF deposition in chickens [7]. Controversy, overexpression of gga-miR-223, as a negative regulator of chicken intramuscular preadipocyte differentiation, significantly reduced the expression of its target gene glycerol-3-phosphate acyltransferase (GPAM), as well as PPARγ and FAPB4, and lead to intramuscular preadipocyte differentiation inhibition and decrease the number of IMF droplets in the adipocyte [52].