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. 2021 Mar 12;10(3):441. doi: 10.3390/antiox10030441

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Systolic blood pressure (SBP) and (B) diastolic blood pressure (DBP) and (C) mean arterial pressure (MAP) measured by tail-cuff method in wild-type mice daily treated with i.p injection of vehicle or PG1 (10 mg/Kg), or in wild-type angiotensin (Ang) II-infused mice daily treated with gavage administration of vehicle or PG1 (10 mg/Kg) mice. Values are means ± SEM. (D) Representative immunoblots conducted on extracts of mesenteric arteries excised at the end of in vivo (14th day) treatment from wild-type mice daily treated with gavage administration of vehicle or PG1 (10 mg/Kg), or in wild-type angiotensin (Ang) II-infused mice daily treated with gavage administration of vehicle or PG1 (10 mg/Kg) mice. (E) Oxidative stress measured by lucigenin assay in mice mesenteric arteries obtained at the end of in vivo treatment. *, p < 0.05; **, p < 0.001; ***, p < 0.0001.