Figure 7.

Effects on the mitochondrial membrane potential (ΔΨm) of diaportheone A1 and diaportheone A2. ΔΨm were evaluated in Aβ-treated (5 μM) SH-SY5Y cells using the tetramethylrhodamine, methyl ester (TMRE) assay. Cells were pretreated with the compounds for 2 h, followed by Aβ treatment for 24 h. The ΔΨm (% of the control cells) was expressed as the mean ± SEM (n = 3). Statistical difference (p < 0.05) of the ΔΨm versus the Abeta-treated alone group (*) or the control group (#) using one-way ANOVA followed by Tukey’s test.