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. 2021 Mar 16;11(3):245. doi: 10.3390/life11030245

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Treg suppression index for CD4⁺ (A) and CD8⁺ (B) cells. The suppression index (SI) was significantly reduced in both groups, healthy donors (HD) and rheumatoid arthritis (RA) patients (for both CD4⁺ and CD8⁺ cells), when the influence of homeostatic cytokines (IL-7 and IL-15) was accompanied by a strong T cell receptor (TCR) stimulation using anti-CD3 antibodies. There were no significant differences in SI between HDs and RA in all conditions of cultivation. Median and IQR. A comparison of related groups was performed using the Friedman test, post hoc analysis was performed using the Dunn test, and unrelated groups were compared using the Mann–Whitney test. RA, rheumatoid arthritis (n = 6); HDs, healthy donors (n = 12); SI, suppression index.