. 2021 Mar 11;57(3):260. doi: 10.3390/medicina57030260

Table 5.

Examples of carcinogenesis with AOM and induced colitis in GF animals.

Species	Chemical	Method of Administation	Incidence GF %	Incidence CV/CVz %	Medical Conditions	Strain	Gender	n. of Animals	Age (Weight) of Animals at the Start of Experiment	Year	Citation
Mice	DSS 5% and 1%	Orally—drinking water	84%	10%	colitis	IQI/Jic	♀	19 (−6†) GF	6–7 weeks	2001	[74]
	DSS 5% and 1%	Orally—drinking water	84%	10%	colitis	IQI/Jic	♀	10 CVz	6–7 weeks	2001	[74]
	DSS 2.5%	orally—drinking water	53%	44%	acute and chronic colitis	BALB/c		15 (−5†) GF	6–7 weeks	2001	[77]
			53%	44%		BALB/c		18 (−4†) CV
			75%	86%		SCID		16 (−8†) GF
			75%	86%		SCID		14 (−6†) CV
	AOM (10 mg/kg), DSS 1–2.5%	orally—drinking water	100% *	0% *	colitis	C57BL/6		GF	6–12 weeks	2013	[82]
	AOM (10 mg/kg), DSS 1–2.5%	orally—drinking water	100% *	0% *	colitis	C57BL/6		CV	6–12 weeks	2013	[82]
Guinea pigs	Carrageenan 5%	orally—drinking water	0%	100%	Cecal ulceration	Hartley strain guinea pigs	♂	6 GF	250–300 g	1981	[72]
Guinea pigs	Carrageenan 5%	orally—drinking water	0%	100%	Cecal ulceration	Hartley strain guinea pigs	♂	142 CV	250–300 g	1981	[72]

Acronyms:.DSS: dextran sodium sulphate; AOM: azoxymethane; SCID: severe combined immundeficiency. * mortality after DSS >2%