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. 2021 Mar 5;9(3):223. doi: 10.3390/vaccines9030223

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of vaccine scale-up duration on the number of vaccinations needed to avert one infection (A), one severe disease case (B), one critical disease case (C), and one death (D) in the United States. The vaccine is assumed to have an efficacy of 95% against infection and is introduced on 1 January 2021, when the cumulative proportion of the population infected is 20%. Duration of both vaccine protection and natural immunity is one year. This scenario assumes a gradual easing of restrictions within 6 months. Corresponding results for China are shown in Figure S8.