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. 2021 Mar 13;22(6):2916. doi: 10.3390/ijms22062916

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sensitivity of 5-FU-resistant HCT116R^F10 and parental HCT116 cells to FUdR, SN-38, and CDDP. Colony formation by HCT116R^F10 and parental HCT116 cells after 10 days of treatment with (a,b) FUdR, (c,d) SN-38, and (e,f) CDDP. Colony formation (%) represents the averages of two independent experiments each performed in duplicate (b) or triplicate (d,f), with error bars showing ±SE of four (b) or six (d,f) measurement values. White circle, HCT116 cells; black circle, HCT116R^F10 cells.