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. 2021 Mar 13;22(6):2925. doi: 10.3390/ijms22062925

Figure 1.

Figure 1

Comparison of viability of THP-1 cells and SaOS-2 cells in 2D and 3D coculture. THP-1 cells and SaOS-2 cells (2:1 ratio) were cocultured over 14 days in 2D and 3D on pHEMA-based cryogel scaffolds. On days 1, 4, 7, 10, and 14 of culture, (A) mitochondrial activity (Resazurin conversion) and (B) cell-specific DNA content were measured. Data are presented as curves or bar charts (mean ± SEM). Changes over time were compared by nonparametric Friedmann test, followed by Dunn’s multiple comparison test. Cell-specific DNA contents were compared by nonparametric two-way ANOVA, followed by Tukey’s multiple comparison test. * p < 0.05, ** p < 0.01, and *** p < 0.0001 as compared to the respective day 1. N ≥ 3 and n = 3.