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. 2021 Mar 6;13(3):346. doi: 10.3390/pharmaceutics13030346

Figure 3.

Figure 3

Rapamycin showed small cytotoxicity in all tested tumor cell lines, although it lead to a decrease in the phosphorylation levels of mTOR at S2448. (A) The most susceptible cell line to rapamycin exposure was FMCp (43.4% of cytotoxicity) followed by the FMCm (41.3% of cytotoxicity) and the CAT-M cell lines (38.7% of cytotoxicity). The human SkBR-3 cell line was used as control, presenting a maximum of 29.6% of cytotoxicity. The experiments were performed in triplicates and repeated three times. (B) Rapamycin reduces the phosphorylation levels of the mTOR at S2448. β-actin was used as loading control.