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. 2021 Mar 10;13(6):1201. doi: 10.3390/cancers13061201

Figure 2.

Figure 2

Structure of the NA binding site in PARPs 1–16. Underlined PARP structures (1–3, 5a, 5b, 10, 12–16) were obtained from the Protein Data Bank, and other structures (4, 6–9, 11) were obtained by homology modeling. Amino acid substitutions in the NA site are marked in red. The NA site architecture is quite similar in PARPs 1–3, 5a, 5b, 10, 12, 14, and 15 due to the lack of substitutions. The coordinates of the 7-MG molecule (colored by atom type) are transferred from the docking model of PARP-1–7-MG complex.