Table 2.

Residues of the NA binding site in PARPs 1–16. Amino acid replacements are marked in gray.

PARP	Residues of the NA Site				PDB ID 1
1	Gly863	Ala898	Ser904	Tyr907	4zzz [54]
2	Gly429	Ala464	Ser470	Tyr473	4zzx [54]
3	Gly385	Ala416	Ser422	Tyr425	4gv2 [55]
4	Gly439	Ser479	Ser485	Tyr488	-
5a	Gly1185	Ala1215	Ser1221	Tyr1224	4w6e/4msg [56,57]
5b	Gly1032	Ala1062	Ser1068	Tyr1071	5nwg [58]
6	Gly474	Ser510	Ser516	Tyr519	-
7	Gly533	Ala566	Ser572	Phe575	-
8	Gly698	Ser734	Ser740	Tyr743	-
9	Gln706	Thr739	Leu745	Lys750	-
10	Gly888	Ala921	Ser927	Tyr932	5lx6 [59]
11	Gly205	Ala238	Ser244	Phe247	-
12	Gly565	Ala598	Ser604	Tyr607	2pqf [60]
13	Ala788	Ala821	Ser827	Asn830	2x5y [60]
14	Gly1602	Ala1635	Ser1641	Tyr1646	3smj [37]
15	Gly538	Ala571	Ser577	Tyr582	4f0e [61]
16	Gly153	Thr184	Ala190	Tyr193	4f0d [62]

¹ Representative crystal structures.