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. 2021 Mar 10;13(6):1191. doi: 10.3390/cancers13061191

Figure 2.

Figure 2

Serine/glycine biosynthesis pathway hyperactivation signatures in cancer. Representation of the frequency of distinct alterations in serine/glycine biosynthesis genes, i.e., PHGDH, PSAT1, PSPH, SHMT1, and SHMT2, across a set of patients for different cancer types. These alterations include mRNA overexpression, somatic mutations, and copy number gain/amplification, which can be associated with serine/glycine biosynthesis pathway hyperactivation signature. The graphs also show the frequencies of mRNA overexpression and mutations/copy number variations separately in each case. This data was collected from the The Cancer Genomic Atlas (TCGA) PanCancer Atlas datasets in cBioPortal.org (data collection July 2020).