Figure 3.

Protein concentrations applied in in vitro LLPS experiments frequently exceed those calculated from proteomics-derived cellular protein abundances. Comparison of protein concentrations used in in vitro LLPS experiments (in blue), concentrations calculated from proteomics-derived cellular protein abundances stored in the PaxDb database (tissue-specific integrated values in orange and cell-line integrated values in green), and local concentrations estimated or referred to by authors (in red) for human LLPS driver proteins integrated from the three LLPS resources and filtered for in vitro verified true LLPS (co)drivers. Concentrations are provided in micromolar units, while LLPS proteins are represented by the respective gene names on the horizontal axis. Functional groups of the proteins are indicated on the top of the figure. For the products of genes LAT, SYN2, and YTHDF3, PaxDb concentration values were not available.