Table 3.
Association of ATG10 SNPs with Acute Myeloid Leukemia (AML). Adjusted odds ratio (OR) and 95% confidence intervals (CIs) for association between SNPs and AML were estimated using logistic regression.
| SNPs | Genotypes | Donors No. (%) | χ2 (pad) |
LR Dominant |
LR Recessive |
|
|---|---|---|---|---|---|---|
| Control | AML | OR (CI) | OR (CI) | |||
| rs1864182 | TT | 77 (25) | 87 (35) | 0.174 | 0.58 (0.42–0.80) p = 0.001; pad = 0.006 |
0.70 (0.47–1.04) p = 0.077; pad = 0.462 |
| TG | 154 (49) | 110 (44) | ||||
| GG | 81 (26) | 53 (21) | ||||
| rs1864183 | CC | 109 (34) | 77 (29) | 1.506 | 1.29 (0.94–1.78) p = 0.113; pad = 0.678 |
1.31 (0.88–1.94) p = 0.180; pad = 1.080 |
| CT | 146 (46) | 126 (47) | ||||
| TT | 63 (20) | 65 (24) | ||||
| rs3734114 | TT | 204 (66) | 168 (68) | 0.012 | 0.86 (0.61–1.22) p = 0.414; pad = 2.484 |
2.70 (1.36–5.34) p = 0.004; pad = 0.024 |
| TC | 92 (30) | 53 (21) | ||||
| CC | 14 (4) | 28 (11) | ||||
Abbreviations: Logistic Regression (LR), Fisher Exact Test (FE), Chi-Square test (χ2), p value (p), adjusted p value using Bonferroni method for multiple testing (pad).