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. 2021 Mar 16;9(3):305. doi: 10.3390/biomedicines9030305

Table 1.

Representative nanomaterials used as PTT agents in combination therapies.

Nanomaterials Combination Therapy Mechanism Ref.
CP-TPP/Au/PEG nanospheres PTT + PDT LTH (808 nm) and ROS (630 nm) [55]
GNc-HyNA PTT + PDT LTH (808 nm) and ROS (690 nm) [56]
GNS-PEG-Ce6 PTT + PDT LTH (671 nm) and ROS (671 nm) [57]
Te-NDs PTT + PDT LTH and ROS (785 nm) [58]
UCNPs-NGO/ZnPC PTT + PDT LTH (808 nm) and ROS (630 nm) [59]
CDAuNs PTT + CT LTH (808 nm) and CDR [60]
DINPs PTT + CT LTH (808 nm) and CDR [61]
HPSN-Pax/PdPc PTT + CT LTH (730 nm) and CDR [62]
Polydopamine-rGO-MSN PTT + CT LTH (808 nm) and CDR [63]
Polypyrrole@MIL-100/DOX PTT + CT LTH (808 nm) and CDR [64]
HCuSNPs-CpG PTT + IT LTH (900 nm) and
SI using small-molecule inhibitors		 [65]
OVA-ICG PTT + IT LTH (808 nm) and
SI as cancer vaccine		 [66]
PCN PTT + IT LTH (808 nm) and
SI as immune agonists		 [67]
PEGylated SWNT PTT + IT LTH (808 nm) and
SI as immune checkpoint blockades		 [68]
piTRLs PTT + IT LTH (808 nm) and
SI using immunostimulant		 [69]
CSA PTT + RT LTH (808 nm) and X-ray [54]
Dox-HGNP PTT + RT LTH (800 nm) and X-ray [70]
mPEG@HGNPs PTT + RT LTH (808 nm) and X-ray [71]
PtNP PTT + RT LTH (808 nm) and X-ray [72]
WS2QDs PTT + RT LTH (808 nm) and X-ray [73]

Abbreviations: CDAuNS: cancer cell membrane-coated doxorubicin-incorporated gold nanocages, CDR: chemo drug release, CpG: cytosine-guanine, CP-TPP: poly(cyclotriphosphazene-co-tetraphenylporphyrin-co-sulfonyldiphenol) nanospheres, CSA: dumbbell-shaped heterogeneous copper selenide-gold nanoparticles, CT: chemotherapy, DINP: PLGA-lecithin-PEG NPs containing DOX and ICG, DOX: doxorubicin, Dox-HGNP: doxorubi-cin-loaded hollow gold nanoparticle, GNc-HyNA: gold-nanoclustered hyaluronan nanoassembly, GNS-PEG-Ce6: chlorin e6-conjugated gold nanostars, GO-PEG-PEI-Ure B: PEG and PEI modified graphene oxide containing urease B, HCuSNPs: hollow Cus nanoparticle, HGNP: hollow gold nanoparticles, HPSN: hollow structured polymer-silica nanohybrid, ICG: indocyanine green, IT: immunotherapy, LTH: light-triggered hyperthermia, NGO: nanographene oxide, OVA: ovalbumine, Pax/PdPc: paclitaxel and palla-dium phthalocyanine, PCN: CpG-integrated OVA@Au nanorod, PEG: polyethylene glycol, PEG-[64Cu]CuS NPs: Copper 64 tagged PEG-coated copper sulfide nanoparticles, piTRLs: poly I:C- and ICG containing thermal responsive liposomes, PLGA: poly(lactic-co-glycolic acid), PtNP: platinum nanoparticles, PTT: photothermal therapy, RT: radiotherapy, ROS: reactive oxygen species generation, SI: stimulation of immune system, SWNT: single-walled carbon nanotubes, Te-NDs: tellurium nanodots, TNP-1: copper-palladium alloy tetrapod nanoparticles, UCNPs: upconversion nanoparticles, WS2QDs: tungsten sulfide quantum dots, X-ray: X-ray irradiation, ZnPc: zinc phthalocyanine.