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. 2021 Mar 16;57(3):274. doi: 10.3390/medicina57030274

Table 2.

Using the Mann–Whitney U test, the mean-term blunt changes in HR and RR were compared with each other due to the use of a given type of medication.

Non-HA (n = 33) HA (n = 16)
M SD Me IQR M SD Me IQR Z p r
HR infusion 1 −1.24 9.30 −1.69 9.92 −5.60 14.88 −0.72 13.64 −0.17 0.865 −0.02
infusion 2 −1.65 8.27 −1.39 6.64 −0.67 7.15 −2.15 9.66 −0.31 0.759 −0.04
infusion 3 −1.75 8.91 −1.00 11.81 −1.44 9.37 0.02 11.20 −0.09 0.932 −0.01
infusion 4 −1.95 11.07 0.00 6.73 −4.75 10.27 −1.29 14.54 −0.80 0.424 −0.11
infusion 5 −4.08 8.17 −2.15 11.47 1.95 10.54 0.00 11.62 −1.65 0.099 −0.24
infusion 6 −2.08 9.42 −1.40 9.77 −1.89 8.17 −2.30 11.04 −0.14 0.887 −0.02
infusion 7 −1.94 10.57 −2.74 13.34 0.72 7.83 0.00 12.97 −1.12 0.262 −0.16
infusion 8 −3.57 13.02 −2.74 9.42 −0.85 10.46 −1.67 10.02 −0.57 0.566 −0.08
RR systolic infusion 1 −0.84 6.78 0.00 7.45 0.77 14.32 0.00 11.69 −0.32 0.749 −0.05
infusion 2 −2.21 6.68 −0.83 7.79 4.96 9.97 7.14 10.17 −2.88 0.004 −0.41
infusion 3 −0.37 8.53 0.00 11.78 1.75 10.20 0.37 4.56 −0.70 0.481 −0.10
infusion 4 −3.88 7.53 −1.64 8.19 −2.28 7.31 −3.32 12.39 −0.26 0.798 −0.04
infusion 5 −0.27 9.83 −1.61 6.60 −0.10 8.41 0.00 10.26 −0.81 0.418 −0.12
infusion 6 −0.37 6.54 0.00 8.69 57.51 227.25 0.00 6.97 −0.31 0.759 −0.04
infusion 7 −1.15 7.94 0.00 9.77 −0.81 12.04 0.00 12.50 −0.12 0.904 −0.02
infusion 8 −2.78 11.79 −3.82 12.85 −1.68 6.50 0.00 7.12 −0.75 0.454 −0.11
RR diastolic infusion 1 −2.90 10.01 −2.78 10.04 6.12 14.69 2.63 16.69 −2.07 0.038 −0.30
infusion 2 −1.89 7.30 0.00 6.05 4.42 12.00 4.22 17.34 −1.70 0.089 −0.24
infusion 3 −2.15 13.75 0.00 15.69 −5.08 18.34 −0.63 20.99 −0.08 0.940 −0.01
infusion 4 −0.53 10.43 0.00 14.47 −4.56 10.34 −0.63 15.61 −0.90 0.368 −0.13
infusion 5 −1.00 9.96 −2.55 10.63 1.32 12.53 0.00 14.12 −0.75 0.456 −0.11
infusion 6 −0.82 10.16 −0.63 8.38 2.23 7.22 0.00 8.34 −1.27 0.204 −0.18
infusion 7 −1.67 11.48 −2.44 8.83 −2.13 6.10 0.00 4.15 −0.68 0.494 −0.10
infusion 8 −1.51 9.78 0.00 13.13 −2.61 8.75 −1.25 10.77 −0.38 0.703 −0.05
Non-DM (n = 46) DM (n = 3)
M SD Me IQR M SD Me IQR Z p r
HR infusion 1 −2.83 11.78 −1.65 12.63 −0.04 3.84 0.00 3.90 −0.50 0.617 −0.07
infusion 2 −1.89 7.75 −2.02 6.74 7.08 3.55 8.33 −3.08 −2.32 0.020 −0.33
infusion 3 −1.72 9.23 −0.50 12.00 −0.52 3.21 −1.37 3.23 −0.08 0.934 −0.01
infusion 4 −2.90 11.06 0.00 8.38 −2.30 6.43 −1.19 9.21 0.00 1.000 0.00
infusion 5 −2.13 9.60 −1.39 10.36 −1.13 5.96 1.16 7.89 −0.49 0.624 −0.07
infusion 6 −2.10 9.06 −1.41 9.76 −0.88 8.27 −4.76 6.49 −0.09 0.932 −0.01
infusion 7 −1.91 9.56 −1.67 10.92 10.10 1.75 9.09 −9.09 −2.32 0.020 −0.33
infusion 8 −3.68 11.95 −2.78 8.96 9.63 9.33 5.00 −3.51 −2.10 0.035 −0.30
RR systolic infusion 1 0.04 9.63 0.00 9.22 −5.78 12.38 0.00 20.00 −0.46 0.646 −0.07
infusion 2 −0.24 8.62 0.00 11.69 6.62 3.05 7.14 −3.33 −1.70 0.088 −0.24
infusion 3 0.11 9.27 0.00 10.58 3.55 4.30 2.33 0.00 −0.88 0.381 −0.13
infusion 4 −3.16 7.37 −2.73 7.69 −6.32 9.25 −9.79 13.33 −0.88 0.381 −0.13
infusion 5 −0.16 9.58 0.00 7.63 −1.04 2.45 0.00 3.85 −0.15 0.881 −0.02
infusion 6 19.75 135.73 0.00 8.07 6.53 18.37 0.00 7.69 −0.04 0.966 −0.01
infusion 7 −2.05 8.02 0.00 10.96 12.14 17.07 4.76 0.00 −1.69 0.092 −0.24
infusion 8 −2.58 10.75 −3.36 9.90 −0.61 1.05 0.00 1.82 −0.56 0.574 −0.08
RR diastolic infusion 1 0.00 12.46 0.00 9.62 0.64 12.80 −1.27 11.11 −0.10 0.917 −0.01
infusion 2 −0.94 8.55 0.00 7.79 17.50 5.88 14.29 −13.92 −2.57 0.010 −0.37
infusion 3 −3.56 15.36 −0.63 16.58 3.93 14.39 10.00 12.50 −0.94 0.348 −0.13
infusion 4 −1.88 10.58 0.00 15.53 −1.44 10.56 0.00 12.64 −0.23 0.818 −0.03
infusion 5 −0.51 11.01 −1.25 10.81 4.00 6.93 0.00 0.00 −0.92 0.358 −0.13
infusion 6 −0.04 9.48 0.00 8.37 3.75 6.50 0.00 0.00 −1.05 0.292 −0.15
infusion 7 −2.10 10.24 −2.38 6.74 1.78 3.08 0.00 0.00 −1.69 0.090 −0.24
infusion 8 −1.55 9.04 0.00 11.64 −5.71 15.05 −7.14 20.00 −0.54 0.591 −0.08
Non-hCh. (n = 40) hCh (n = 9)
M SD Me IQR M SD Me IQR Z p r
HR infusion 1 −2.00 12.13 0.00 11.38 −5.60 7.57 −1.69 8.32 −1.23 0.220 −0.18
infusion 2 −1.21 8.26 −1.52 6.93 −1.84 6.14 0.00 9.51 −0.16 0.874 −0.02
infusion 3 −1.91 8.88 −0.50 11.27 −0.49 9.78 −1.37 17.03 −0.32 0.747 −0.05
infusion 4 −3.02 11.19 0.00 6.58 −2.14 9.34 −1.19 17.75 −0.12 0.907 −0.02
infusion 5 −1.00 9.78 0.00 8.82 −6.70 5.62 −7.89 9.98 −2.15 0.031 −0.31
infusion 6 −1.59 9.43 −1.39 9.83 −3.87 6.47 −4.76 9.37 −0.49 0.625 −0.07
infusion 7 −0.27 9.35 −0.68 11.06 −4.39 11.26 −7.32 22.33 −0.98 0.328 −0.14
infusion 8 −2.60 11.86 −2.70 9.28 −3.31 15.29 −5.36 22.41 −0.46 0.645 −0.07
RR systolic infusion 1 0.81 9.79 0.00 7.67 −5.33 8.37 −1.34 14.03 −1.52 0.127 −0.22
infusion 2 −0.03 8.43 0.00 11.05 1.13 9.41 3.33 9.47 −0.73 0.467 −0.10
infusion 3 0.14 9.44 0.00 10.47 1.12 7.54 0.74 10.19 −0.56 0.579 −0.08
infusion 4 −2.56 7.68 −1.16 8.15 −6.90 5.01 −7.69 5.65 −2.09 0.036 −0.30
infusion 5 −0.65 8.73 0.00 8.89 1.69 11.82 0.00 5.39 −0.04 0.968 −0.01
infusion 6 22.85 145.76 0.00 7.94 1.90 12.20 0.00 16.34 −0.16 0.874 −0.02
infusion 7 −0.54 9.29 0.00 10.31 −3.13 9.95 1.57 16.77 −0.08 0.936 −0.01
infusion 8 −2.57 11.16 −2.18 10.39 −1.68 3.03 −0.91 5.72 −0.23 0.815 −0.03
RR diastolic infusion 1 0.31 12.97 0.00 10.43 −1.15 9.63 −4.55 15.64 −0.85 0.393 −0.12
infusion 2 0.31 8.80 0.00 10.55 −0.20 12.73 −2.22 15.42 −0.49 0.624 −0.07
infusion 3 −1.54 13.41 0.00 19.34 −10.05 21.34 −7.69 12.50 −1.20 0.230 −0.17
infusion 4 −2.47 9.89 0.00 11.39 0.93 13.04 4.00 25.91 −1.01 0.311 −0.14
infusion 5 0.25 11.33 0.00 12.20 −2.31 8.37 −2.25 7.14 −0.93 0.354 −0.13
infusion 6 −0.17 9.82 0.00 8.45 1.78 6.96 0.00 10.59 −0.96 0.337 −0.14
infusion 7 −1.01 10.45 −0.62 6.43 −5.28 6.84 −3.41 8.61 −0.85 0.393 −0.12
infusion 8 −1.71 9.42 −0.75 11.68 −2.69 9.96 −0.63 12.89 −0.09 0.928 −0.01
Non-Stroke (n = 46) Stroke (n = 3)
M SD Me IQR M SD Me IQR Z p r
HR infusion 1 −2.84 11.78 −1.53 12.54 0.17 3.23 −1.69 1.69 −0.42 0.677 −0.06
infusion 2 −1.29 8.09 −1.52 7.19 −1.80 3.12 0.00 5.41 −0.28 0.782 −0.04
infusion 3 −1.71 8.79 −1.15 10.93 −0.64 13.70 7.27 16.46 −0.71 0.478 −0.10
infusion 4 −3.33 10.93 −0.60 10.19 4.29 4.94 7.14 1.41 −1.21 0.226 −0.17
infusion 5 −1.85 9.47 −1.39 9.73 −5.47 8.35 −10.29 10.29 −0.66 0.509 −0.09
infusion 6 −2.36 9.13 −2.94 9.71 3.04 0.32 3.23 −2.67 −1.68 0.092 −0.24
infusion 7 −0.73 9.83 −0.68 12.82 −7.65 5.09 −7.65 11.25 −1.30 0.194 −0.19
infusion 8 −2.65 12.35 −2.18 11.24 −5.06 - −5.06 0.00 −0.59 0.554 −0.08
RR systolic infusion 1 −0.53 10.05 −0.39 10.01 2.86 1.23 3.57 −1.45 −1.50 0.133 −0.21
infusion 2 −0.14 8.67 0.00 11.69 5.13 4.44 7.69 0.00 −1.24 0.217 −0.18
infusion 3 0.33 8.87 0.00 9.40 0.22 14.05 8.33 16.00 −0.42 0.676 −0.06
infusion 4 −3.09 7.58 −1.95 8.99 −7.51 0.32 −7.69 7.69 −1.21 0.226 −0.17
infusion 5 0.17 9.45 0.00 7.29 −5.90 3.55 −3.85 10.00 −1.64 0.101 −0.23
infusion 6 20.05 135.73 0.00 7.91 1.99 11.62 8.70 11.43 −0.70 0.482 −0.10
infusion 7 −0.81 9.45 0.00 10.74 −5.56 7.86 −5.56 11.11 −0.89 0.375 −0.13
infusion 8 −2.50 10.49 −1.82 9.90 0.00 - 0.00 0.00 −0.50 0.620 −0.07
RR diastolic infusion 1 0.54 12.57 0.00 10.20 −7.63 3.02 −5.88 11.11 −1.69 0.091 −0.24
infusion 2 0.23 9.81 0.00 13.18 0.00 0.00 0.00 0.00 −0.19 0.847 −0.03
infusion 3 −3.47 15.67 −1.27 18.17 2.50 4.33 0.00 0.00 −0.58 0.559 −0.08
infusion 4 −2.75 10.02 0.00 15.32 11.97 8.14 16.67 −2.56 −2.31 0.021 −0.33
infusion 5 0.07 11.07 0.00 11.23 −4.76 4.12 −7.14 7.14 −1.00 0.315 −0.14
infusion 6 −0.81 8.69 0.00 6.48 15.27 4.10 12.90 −12.90 −2.60 0.009 −0.37
infusion 7 −1.76 10.16 −1.81 6.64 −2.94 4.16 −2.94 5.88 −0.06 0.953 −0.01
infusion 8 −2.07 9.39 −1.25 11.41 7.14 - 7.14 0.00 −1.20 0.231 −0.17
Non-Epileptic (n = 43) Epileptic (n = 6)
M SD Me IQR M SD Me IQR Z p r
HR infusion 1 −2.39 11.57 −1.45 10.65 −4.58 11.35 −4.01 18.91 −0.64 0.522 −0.09
infusion 2 −2.04 7.84 −2.27 6.94 3.69 6.39 0.70 12.69 −1.89 0.059 −0.27
infusion 3 −1.67 9.02 0.00 10.89 −1.46 9.40 −1.48 17.69 −0.15 0.879 −0.02
infusion 4 −3.47 10.46 −1.19 6.43 1.51 13.15 7.44 23.59 −1.50 0.135 −0.21
infusion 5 −2.46 9.52 −1.42 9.89 0.67 8.44 1.09 12.20 −0.92 0.358 −0.13
infusion 6 −1.67 8.99 −1.44 9.60 −4.50 8.89 −3.25 15.05 −0.56 0.575 −0.08
infusion 7 −0.49 10.08 −0.68 12.36 −4.42 7.02 −4.67 12.67 −0.99 0.323 −0.14
infusion 8 −2.21 12.69 −1.67 12.32 −5.61 9.17 −3.11 10.18 −0.72 0.472 −0.10
RR systolic infusion 1 −0.26 10.10 0.00 7.80 −0.72 7.65 0.76 13.43 −0.24 0.807 −0.03
infusion 2 0.23 8.69 0.00 11.91 −0.15 8.07 2.27 12.84 −0.14 0.888 −0.02
infusion 3 0.93 8.94 0.00 9.17 −4.05 9.47 −4.43 14.55 −1.44 0.151 −0.21
infusion 4 −2.74 6.51 −1.64 8.70 −7.80 12.07 −4.92 12.84 −0.81 0.419 −0.12
infusion 5 −0.73 9.20 −0.77 6.02 3.38 9.97 4.55 15.77 −1.14 0.255 −0.16
infusion 6 21.89 140.43 0.00 8.56 −1.83 7.15 0.41 8.47 −0.14 0.888 −0.02
infusion 7 −0.14 9.33 0.00 11.08 −6.38 8.22 −4.55 13.43 −1.64 0.102 −0.23
infusion 8 −1.35 10.63 0.00 7.97 −8.97 5.63 −8.12 9.87 −2.38 0.017 −0.34
RR diastolic infusion 1 −0.73 11.65 −1.20 8.85 5.56 16.76 5.83 22.59 −1.65 0.099 −0.24
infusion 2 −0.05 9.54 0.00 9.28 2.06 9.87 0.00 15.48 −0.58 0.562 −0.08
infusion 3 −1.73 15.42 0.00 17.79 −12.94 10.33 −12.14 19.47 −2.08 0.038 −0.30
infusion 4 −1.29 9.75 0.00 16.07 −5.86 15.25 −6.53 19.52 −0.86 0.390 −0.12
infusion 5 −1.19 10.02 −0.63 10.34 6.50 14.55 2.00 21.38 −1.22 0.223 −0.17
infusion 6 0.72 8.96 0.00 8.07 −3.50 11.80 −1.88 19.67 −0.61 0.539 −0.09
infusion 7 −2.53 7.82 0.00 6.64 2.45 18.87 −3.28 15.68 −0.49 0.626 −0.07
infusion 8 −0.63 9.10 0.00 12.29 −9.17 8.22 −9.35 14.77 −1.91 0.057 −0.27

HA—arterial hypertension; DM—diabetes mellitus; hCh—hypercholersterolemia.