Table 4.
Results of the GMDS-ER analysis in EGCG-treated DS children.
| Items | DS-EGCG (1–8 y) (n = 14) Group 1 |
p-Value | DS-EGCG (≤ 2 y) (n = 7) Group 1a |
p-Value | DS-EGCG (2–8 y) (n = 7) Group 1b |
p-Value | |||
|---|---|---|---|---|---|---|---|---|---|
| T0 | T6 | T6 vs. T0 | T0 | T6 | T6 vs. T0 | T0 | T6 | T6 vs. T0 | |
| Chronologica age (CA) | 41 ± 26 | 47 ± 26 | n.s | 20 ± 4 | 26 ± 4 | n.s | 62.5 ± 20 | 69 ± 20 | n.s |
| General Quotient—Age-Equivalent (AE) | 22 ± 12 | 24 ± 11 | n.s | 14 ± 3 | 18 ± 3 | 0.05 | 29 ± 12 | 30 ± 12 | n.s |
| Gap between chronological age and AE general quotient (CA-AE) | 19 ± 16 | 23 ± 18 | <0.01 | 6 ± 3 | 8 ± 4 | n.s | 33 ± 12 | 38 ± 12 | n.s |
| Locomotor (subscale A) | 21 ± 12 | 25 ± 14 | <0.01 | 13 ± 4 | 16 ± 4 | n.s | 30 ± 12 | 35 ± 15 | n.s |
| Personal-Social (subscale B) | 24 ± 18 | 29 ± 18 | <0.01 | 15 ± 4 | 19 ± 4 | <0.05 | 33 ± 16 | 39 ± 21 | <0.05 |
| Language (subscale C) | 20 ± 12 | 23 ± 15 | <0.01 | 12 ± 2 | 15 ± 2 | <0.05 | 27 ± 14 | 31 ± 19 | n.s |
| Eye and Hand Co-ordination (subscale D) | 24 ±14 | 27 ± 16 | n.s | 15 ± 5 | 18 ± 3 | n.s | 3S3 ± 14 | 36 ± 19 | n.s |
| Performance (subscale E) | 21 ± 9 | 23 ± 11 | <0.01 | 16 ± 5 | 17 ± 3 | n.s | 27 ± 9 | 30 ± 17 | n.s |
| Practical Reasoning (subscale F) | NA | NA | n.s | NA | NA | NA | 30 ± 8 | 33 ± 11 | n.s |
DS, Down syndrome; NA, not applicable; n.s, not significant. All data are expressed in months (mean ± SD). Data have been analyzed as entire group and subgroups according to chronological age at enrolment ≤ 2 years and 2–8 years. Practical Reasoning (subscale F) is present only in the GMDS-ER 2–8 and applies to children aged 2–8 years.