Table 2.
In vitro anticancer activities of synthesized coumarins compared with doxorubicin and acridine orange.
| Compounds | R | IC50 (µM) | ||
|---|---|---|---|---|
| Cancer Cell Line | Normal Cell Line | |||
| HepG2 | HeLa | LLC-MK2 | ||
| 10 | - | > 100 | 80.38 | > 100 |
| 12 | 4-H | 2.35 | > 100 | > 100 |
| 13 | - | 81.73 | 26.42 | 37.95 |
| 14a | 4-H | 4.33 | 10.40 | 0.48 |
| 14b | 4-F | 4.85 | 0.75 | >100 |
| 14c | 4-Cl | 30.28 | 14.04 | 66.80 |
| 14d | 4-Br | 45.76 | 37.36 | > 100 |
| 14e | 2,5-diF | 2.62 | 0.39 | 1.33 |
| 14f | 4-CH3 | > 100 | > 100 | 85.31 |
| 14g | 4-OCH3 | > 100 | > 100 | > 100 |
| 15 | - | 9.13 | 13.47 | 6.87 |
| Doxorubicin | - | 1.91 | 1.18 | 63.47 |
| Acridine orange | - | 5.72 | 6.59 | 82.30 |