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. 2021 Mar 16;10(3):660. doi: 10.3390/cells10030660

Figure 3.

Figure 3

Constituents of mTORC and mTOR signaling in the cell. mTORC1 includes mTOR, Raptor, mLST8, PRAS40 and DEPTOR, while mTORC2 contains mTOR, Rictor, mSIN1, Protor-1, mLST8 and DEPTOR. Abbreviations: RHEB: ras homolog enriched in brain; GDP: guanosine diphosphate; GTP: guanosine triphosphate; PRAS40: proline-rich Akt substrate 40 kDa; mLST8: mammalian lethal with Sec13 protein 8; Raptor: the regulatory-associated protein of mTOR; DEPTOR: DEP-domain-containing mTOR-interacting protein; TFEB: transcription factor EB; HIF1α: hypoxia inducible factor 1α; ATF4: activating transcription factors 4; 4EBP: 4E binding protein; eIF4F: eukaryotic initiation factor 4F; eIF4B: eukaryotic initiation factor 4B; CAD: carbamoyl-phosphate synthetase; S6K: S6 kinase; SGK1: glucocorticoid induced protein kinase 1; MDM2: murine double minute 2; Akt: protein kinase B; PI3K: phosphoinositide 3-kinase; PTEN: phosphatase and tensin homolog; BDNF: brain-derived neurotrophic factor; mSIN1: mammalian stress-activated protein; Protor-1: protein observed with Rictor-1; Rictor: rapamycin-insensitive companion of mTOR; PKCα: protein kinase Cα.