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. 2021 Mar 16;22(6):3031. doi: 10.3390/ijms22063031

Figure 5.

Figure 5

TT and MZ-CRC-1 implanted cells stimulate angiogenesis in zebrafish embryos after only 24 h post-injection. Representative fluorescence images of 72 hpf Tg(fli1a:EGFP)y1 zebrafish control embryos (a) and embryos implanted at 48 hpf with TT (b,d) and MZ-CRC-1 cells (c,e). The red channel, corresponding to TT or MZ-CRC-1 cells, was omitted in panels b and c to highlight the tumor-induced microvascular network. Compared to the control, grafted embryos showed vessels in green that sprout from the sub-intestinal vein (SIV) toward the xenograft of both cell lines. Embryos are shown anterior to the left. Scale bar: 100 µm.