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. 2021 Mar 16;22(6):3038. doi: 10.3390/ijms22063038

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The roles of HSP27 in physiology, pathology, and therapy. (A) At physiological levels, HSP27 main function is protein homeostasis. Unbalanced HSP27 levels have been related to different pathological conditions: elevated levels of HSP27 have been found in patients with viral infections, including those with coronavirus disease 2109 (COVID-19), several types of cancer, and morphine addiction, while a decrease in its levels has been linked to different neurodegenerative diseases. (B) Due to its implication in several disorders, modulating the levels of HSP27 has been proposed as interesting therapeutic option.