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In vivo determined absolute changes relative to basal values of pH for investigated creams (active cream—WB, placebo cream—P) after 7, 14, 28 days of application and 2 days after cessation of application (blue, red, green and purple bar, respectively), compared to untreated control (C). Significant differences are being marked with # (p < 0.01) and * (p < 0.05).
