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. 2021 Mar 17;22(6):3059. doi: 10.3390/ijms22063059

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Tocilizumab structure. Tocilizumab is a recombinant humanized IgG1κ antibody, consisting of two identical light chains, each one including a variable (V_L) and a constant (C_L) domain, coupled to two identical heavy chains, each one including a variable domain (V_H) and three constant domains (C_H). Overall, this antibody structure includes 12 intrachain and 4 interchain disulfide bonds. The variable portion of tocilizumab includes the complementarity-determining regions (CDR), which bind the IL-6 receptor. This original figure was created by the authors using BioRender.com.