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The model of trans-mesothelial migration of ovarian cancer (OvCa) cells. OvCa cells stimulate mesothelial cells (MCs) to transition into OvCa-associated MCs (OCAMs), which in turn enhance the adhesion of OvCa cells to mesothelial tissue. This adhesion triggers OCAMs to expand the intercellular gap by their own migration. Then, OCAMs invite the OvCa cells to pass through the intercellular gap and enter the sub-mesothelial space.
