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Box–Behnken design experimental dependent and independent variables with levels (low, medium and high) employed in the fabrication of PLM-loaded GMs.
| Independent Variables | Level Used | ||
|---|---|---|---|
| Low (−1) | Medium (0) | High (+1) | |
| X1: Phospholipid conc. (mg) | 15 | 22.5 | 30 |
| X2: Cholesterol (mg) | 1 | 2.5 | 4 |
| X3: Glycerol | 10 | 20 | 30 |
| Dependent variables | |||
| Y1: Vesicles size (nm) | Minimize | ||
| Y2: Entrapment efficiency (%) | Maximize | ||
| Y3: Drug permeation/Flux (μg/cm2/h) | Maximize | ||
