Figure 1.

Mechanisms of FXIII activation. (A) Thrombin- and Ca²⁺-driven cleavage of FXIIIA₂B₂. (B) Non-proteolytic activation of cellular FXIII-A by low Ca²⁺. The green and purple cylinders represent β-barrel and β-sandwich domains of FXIII-A subunit, respectively. The core domains in FXIII-A subunit are shown in orange and the activation peptides are shown in red. The inhibitory B subunits are shown in grey. Adapted from the work in [1].