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Effect of BBR and DDP alone and in combination on MAPK signaling. (A,B) Cells were treated with BBR or/and DPP for 48 h. The levels of cleaved MAPK were detected by Western blotting. The data are presented as the mean ± SD of three independent experiments; ** p < 0.01, compared with the control group. ## p < 0.01, compared with the monotherapy group.
