Figure 4.
Perfusion culture bioreactor and FEM analysis of nutrients and waste mass exchange in static and dynamic conditions. Schematic illustration of the static (a) and dynamic (b) environment for the 3D scaffolds culture and related FEM analysis of nutrient consumption and waste production in both static vs. dynamic condition; molecule concentrations are represented as mean value and are expressed as mol/m3. Perfusion bioreactor images and 3D scaffold details (c) and FEM analysis of medium velocity profile (grey lines) and distribution (horizontal cross-section) within a single culture well (the perfusion flow is oriented along the y-direction) (d).