Table 1.

Candidate Genetic Variants.

Family	# of Affected Carriers	# of Unaffected Carriers I	Gene	Transcript	Protein Change	GnomAD Exome MAF	AnnEx State (Count)	PD Genetics	UKB II and MGRB	CADD (Phred)
#002	5	2	KCNJ15	NM_001276436	p.R28C	1.22 × 10−5	Non-PD (1)	0	4	16.9
			SON	NM_138927	p.S1595P	4.06 × 10−5	0	0	13	2.864
		3	PASK	NM_001252120	p.P519L	2.03 × 10−5	0	2	3	11.58
#431	3	2	ARL14EP	NM_152316	p.A146V	0.00	0	0	0	21.5
			HYDIN	NM_001270974	p.A2271E	4.44 × 10−6	0	0	0	4.081
			PTPRA	NM_080840	p.R223W	5.32 × 10−5	Non-PD (2)	0	43	28.6
#433	3	1	SIPA1L1	NM_001284247	p.R236Q	2.85 × 10−5	0	0	13	16.02
#447	3	1	ZNF462	NM_021224	p.I1523V	4.06 × 10−6	0	0	0	11.9
			DUSP19	NM_001142314	p.I111R	4.06 × 10−6	0	0	0	24
			KCTD1	NM_001136205	p.G134R	4.07 × 10−6	0	0	0	4.792
			TAF1C	NM_001243158	p.R346Q	8.29 × 10−6	0	1	0	2.672
			DARS2	NM_018122	p.S59L	1.22 × 10−5	0	0	0	15.29
			EXPH5	NM_001144765	p.T920S	2.88 × 10−5	0	0	1	10.15
			FAM71B	NM_130899	p.I318T	6.10 × 10−5	Non-PD (2) III	1	2	0.01
			CCDC180	NM_020893	p.R1684C	8.53 × 10−5	0	0	3	12.13
#484	3	1	TCP10L	NM_144659	p.I54F	0.00	0	0	0	5.434
			ADCY4	NM_001198568	p.H760Q	4.10 × 10−6	0	0	6	11.05
			USP42	NM_032172	p.H952R	5.69 × 10−6	0	0	1	14.75
			UNC13B	NM_006377	c.3188+1G>A	1.63 × 10−5	0	1	0	25.6
			CFTR	NM_000492	p.K1080R	2.85 × 10−5	Non-PD (2)	0	1	28.7
			NINL	NM_025176	p.Q1232H	3.58 × 10−5	0	0	9	12.17
			CST5	NM_001900	p.S66N	3.67 × 10−5	Non-PD (3)	4	12	11.77
#460	3 IV	1	SLC2A12	NM_145176	p.S357L	0.00	0	0	0	22
			DOCK3	NM_004947	p.R392W	0.00	0	0	0	18.96
			TPR	NM_003292	p.K1038N	0.00	0	0	4	16.34
			DNAH1	NM_015512	p.K1792R	4.06 × 10−6	0	0	0	21.3
			PCDHGA7	NM_018920	p.S667G	1.63 × 10−5	Non-PD (1)	1	12	12.13
			MYOT	NM_001135940	p.N30K	2.03 × 10−5	Non-PD (1)	1	10	6.21
			KIF9	NM_022342	p.R287W	2.44 × 10−5	0	0	0	20.4
			DNAJC12	NM_021800	p.T99M	4.06 × 10−5	Non-PD (1)	2	6	14.86
			SLAMF8	NM_020125	p.V234E	7.31 × 10−5	Non-PD (1)	2	21	17.11
			ZNF75A	NM_153028	p.Q212E	8.95 × 10−5	Non-PD (1), PD(2) V	0	28	14.51

I Carriers >80 years, II UKB controls, III Frontotemporal Dementia, IV Undiagnosed tremor not included, V family #006. Minor Allele Frequency: MAF; Parkinson’s disease: PD; United Kingdom BioBank: UKB; Medical Genome Reference Bank: MGRB; Combined Annotation Dependent Depletion: CADD. (1)–(3): These are the counts of that state.