CRC	colorectal cancer
CTC	circulating tumour cell
ECM	extracellular matrix
EMT	epithelial–mesenchymal transition
FTase	farnesyltransferase
GAP	GTPase activating proteins
GEP	guanine nucleotide exchange factors
HVR	hypervariable region
ISC	intestinal stem cell
KRASmut	mutant KRAS
KRASwt	wild type KRAS
mCRC	metastatic CRC
miRNA	microRNA
PM	plasma membrane
PTM	posttranslational modifications
SCFA	short chain fatty acid