Table 2.

The binding details of all compounds against the Mutant 1 (Y54C) Mpro.

Protein	Inhibitor	Score	Residues
			Hydrogen Bond	Pi Interactions
Mutant 1 (Y54C)	PF-00835231	73.17	L141, G143, S144, C145, E166, Q189	M49, P168
	Manidipine	66.68	T26, S46	C145, M165
	Boceprevir	65.96	T26, G143, C145, E166, Q189	H41, M49, H163, M165
	Lercanidipine	65.28	T26, G143, C145	L27, H41, M165
	Efonidipine	68.23	L141, G143, S144, Q189	L27, C145, H163, P168, H172
	Bedaquiline	63.27	H164	L27, H41, M49, C145