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. 2021 Mar 17;13(3):498. doi: 10.3390/v13030498

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed neuroinvasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and interrelationship between the hypothalamus and olfactory system. (A) Sagittal view of olfactory bulb, primary olfactory cortex, and the hypothalamus. (B) Complex connection between hypothalamic circuits and primary olfactory cortex (reproduced with permission from [70]). Abbreviations: ACN, amygdaloïd cortical nucleus; AON, anterior olfactory nucleus; ARC, arcuate nucleus; DMH, dorsomedial nucleus of the hypothalamus; EBOP, extra bulbar olfactory pathway; EC, entorhinal cortex; LH, lateral hypothalamus; OB, olfactory bulb; OE, olfactory epithelium; OT, olfactory tubercle; Pir, Piriform cortex; POA, preoptic area; PVN, paraventricular nucleus of the hypothalamus; TT, taenia tecta; VMH, ventromedial nucleus of the hypothalamus.