Table 1.

Differences in the incidence and severity of side effects after the first dose of the COVID-19 vaccine among participants who had or did not have a prior COVID-19 infection.

Side Effect	Incidence of Side Effects: Risk Ratio (95% CI)	Incidence of Side Effects: Multivariate Logistic Regression, Coefficient (p-Value)	Severity of Side Effects: Univariate Cumulative Risk Models (p-Value)	Severity of Side Effects: Multivariate Cumulative Risk Models (p-Value)
Any side effect	1.08 (1.05–1.11)	0.575 (0.004)	<0.001	<0.001
Localized reaction	1.10 (1.06–1.15)	0.45 (0.003)	<0.001	0.003
Fever	2.24 (1.86–2.70)	0.876 (<0.001)	NS	NS
Flu-like illness	1.78 (1.51–2.10)	0.658 (<0.001)	NS	NS
Shortness of breath	2.05 (1.28–3.29)	0.651 (0.011)	NS	NS
Skin rash	1.04 (0.54–2.00)	NS	NS	NS
Tingling	1.26 (0.83–1.91)	NS	NS	NS
Swelling	1.00 (0.32–3.14)	NS	NS	NS
Generalized swelling	1.84 (0.94–3.60)	NS	NS	NS
Anaphylaxis	0.55 (0.06–4.72)	NS	NS	NS
Fatigue or tiredness	1.34 (1.2–1.49)	0.418 (<0.001)	<0.001	<0.001
Other	1.46 (1.16–1.82)	0.349 (0.013)	NS	NS
		Worse outcomes associated with a prior COVID-19 infection