Table 3.
Differences in the incidence and severity of side effects after the second or the first dose of the vaccine.
| Side Effect | Incidence of Side Effects: Risk Ratio (95% CI) | Incidence of Side Effects: Multivariate Logistic Regression, Coefficient (p-Value) | Severity of Side Effects: Univariate Cumulative Risk Models (p-Value) | Severity of Side Effects: Multivariate Cumulative Risk Models (p-Value) |
|---|---|---|---|---|
| Any side effect | 1.04 (1.01–1.07) | NS | NS | NS |
| Localized reaction | 0.98 (0.94–1.03) | 2.469 (<0.001) | NS | NS |
| Fever | 1.72 (1.46–2.02) | 1.3 (<0.001) | NS | NS |
| Flu-like illness | 1.67 (1.45–1.91) | 0.979 (0.001) | NS | NS |
| Shortness of breath | 0.95 (0.57–1.61) | 4.491 (<0.001) | NS | NS |
| Skin rash | 2.25 (1.4–3.62) | 4.297 (<0.001) | 0.05 | NS |
| Tingling | 1.31 (0.89–1.92) | 3.096 (<0.001) | NS | NS |
| Swelling | 2.03 (0.87–4.77) | NS | NS | NS |
| Generalized swelling | 1.2 (0.61–2.34) | 4.925 (<0.001) | NS | NS |
| Anaphylaxis | 2.54 (0.72–8.98) | 4.747 (0.012) | NS | NS |
| Fatigue or tiredness | 1.4 (1.28–1.53) | 0.868 (<0.001) | NS | NS |
| Other | 1.05 (0.83–1.32) | 2.104 (<0.001) | NS | NS |
| Worse outcomes after the second COVID-19 vaccine dose | ||||