Table A3.

Differences in the incidence and severity of side effects after the first dose of a COVID-19 vaccine among participants who had or did not have a prior self-reported COVID-19 infection. Sensitivity analysis only included participants with a prior COVID-19 infection confirmed with a consistent PCR or antibody test (n = 366) versus those without any suspicion of a prior COVID-19 infection (n = 1470).

Side Effect	Incidence of Side Effects: Risk Ratio (95% CI)	Incidence of Side Effects: Multivariate Logistic Regression, Coefficient (p-Value)	Severity of Side Effects: Univariate Cumulative Risk Models (p-Value)	Severity of Side Effects: Multivariate Cumulative Risk Models (p-Value)
Any side effect	1.09 (1.05–1.12)	0.581 (0.015)	<0.001	0.004
Localized reaction	1.11 (1.06–1.16)	0.411 (0.019)	0.002	NS
Fever	2.45 (2.01–3)	0.902 (<0.001)	NS	NS
Flu-like illness	1.92 (1.61–2.29)	0.691 (<0.001)	NS	NS
Shortness of breath	2.06 (1.22–3.49)	0.564 (0.043)	NS	NS
Skin rash	1.38 (0.7–2.71)	NS	NS	NS
Tingling	1.22 (0.75–1.98)	NS	NS	NS
Swelling	0.73 (0.16–3.28)	NS	NS	NS
Generalized swelling	1.72 (0.8–3.73)	NS	NS	NS
Anaphylaxis	0.8 (0.09–6.85)	NS	NS	NS
Fatigue or tiredness	1.39 (1.24–1.56)	0.459 (<0.001)	<0.001	0.002
Other	1.45 (1.12–1.87)	0.288 (0.069)	NS	NS
		Worse outcomes associated with a prior COVID-19 infection