Table 1.
Drugs used in in vitro models for defatting of steatotic hepatocytes.
| Model | n | Defatting Agents | Main Outcomes | |
|---|---|---|---|---|
| Pégorier et al., 1989 [16] |
rat hepatocytes | 8 | glucagon, forskolin and c-AMP |
induction of ketogenesis |
| Berthiaume et al., 2009 [8] |
rat hepatocytes | 14 | None | steatosis reversal |
| Nagrath et al., 2009 [18] | Rat hepatocytes | 4 | combination of visfatin, forskolin, hypericin and nuclear receptor ligands (GW7, GW5, scoparone) | reduction of intracellular TGcontent promotion of lipid export |
| Nativ et al., 2014 [19] |
rat hepatocytes | 6 | defatting cocktail | reduction of intrahepatic TG reduction of large lipid droplets |
| Yarmush et al., 2015 [21] |
HepG2 cells | 3 | combination of visfatin, forskolin, hypericin and nuclear receptor ligands (GW7, GW5, scoparone) | decrease of TG content |
| Boteon et al., 2018 [23] |
human hepatocytes from discarded donor livers HIEC, cholangiocytes |
4 | combination of visfatin, forskolin, hypericin, L-carnithine, PPARα ligand and nuclear receptor ligands (GW7, GW5, scoparone) | reduction of intracellular TG induction of fatty acids β-oxidation |
| Aoudjehane et al., 2020 [24] |
human hepatocytes from fatty livers | 6 | forskolin, L-carnitine and PPARα agonist | reduction of intracellular TG |
| Madji et al., 2020 [20] |
mice livers human steatotic hepatocytes |
10 10 |
RIPA-56 | decrease of intracelliular lipid droplets and TG content decreased inflammation and liver injury |
| Pégorier et al., 1989 [16] |
rat hepatocytes | 8 | glucagon, forskolin and c-AMP |
induction of ketogenesis |
| Berthiaume et al., 2009 [8] |
rat hepatocytes | 14 | NA | reversing of steatosis |
| Nativ et al., 2014 [19] |
rat hepatocytes | 6 | defatting cocktail | reduction of intrahepatic TG reduction of large lipid droplets |
| Yarmush et al., 2015 [21] |
HepG2 cells | 3 | combination of visfatin, forskolin, hypericin and nuclear receptor ligands (GW7, GW5, scoparone) | decrease of TG content |
| Boteon et al., 2018 [23] |
human hepatocytes from discarded donor livers HIEC, cholangiocytes |
4 | combination of visfatin, forskolin, hypericin, L-carnithine, PPARα ligand and nuclear receptor ligands (GW7, GW5, scoparone) | reduction of intracellular TG induction of fatty acids β-oxidation |
| Aoudjehane et al., 2020 [24] |
human hepatocytes from fatty livers | 6 | forskolin, L-carnitine and PPARα agonist | reduction of intracellular TG |
| Madji et al., 2020 [20] |
mice livers human steatotic hepatocytes |
10 10 |
RIPA-56 | decrease of intracelliular lipid droplets and TG content decreased inflammation and liver injury |
AMP: cyclic adenosine monophosphate; TG: triglycerides; HIEC: human intra-hepatic endothelial cells.