Table 2.
Factors associated with appropriate or inappropriate prescription.
| Variables | Appropriate Prescription | Inappropriate Prescription | p Value |
|---|---|---|---|
| N° of Antimicrobial prescriptions | 65 | 143 | − |
| Antibiotic prophylaxis, N (%) | 16 (24.6) | 62 (43.4) | 0.01 |
| Antibiotic therapy, N (%) | 49 (75.4) | 81 (56.6) | 0.01 |
| Prescriptions in non-ASP units, N (%) | 38 (58.5) | 129 (90.2) | <0.01 |
| Prescriptions in ASP units N (%) | 27 (41.5) | 14 (9.8) | <0.01 |
| Characteristics of Units | |||
| Medical units, N (%) | 33 (50.8) | 41 (28.7) | <0.01 |
| Surgical units, N (%) | 22 (33.8) | 94 (65.7) | <0.01 |
| Intensive care units, N (%) | 10 (15.4) | 8 (5.6) | 0.02 |
| Appropriateness of antibiotic therapy prescription | |||
| Empiric therapy, n/N (%) | 25/49 (51.0) | 72/81 (88.9) | <0.01 |
| Prescriptions in non-ASP units, n/N (%) | 30/49 (61.2) | 73/81 (90.1) | <0.01 |
| Prescriptions in ASP units, n/N (%) | 19/49 (38.8) | 8/81 (9.9) | <0.01 |
| Acquisition of infection | |||
| Community-acquired infection, n/N (%) | 30/49 (61.2) | 44/81 (54.3) | 0.44 |
| Healthcare-associated infection, n/N (%) | 5/49 (10.2) | 5/81 (6.2) | 0.40 |
| Nosocomial infection, n/N (%) | 11/49 (22.4) | 20/81 (28.9) | 0.04 |
| Unknown, n/N (%) | 3/49 (6.2) | 12/81 (14.8) | 0.13 |
| Severity of infection | |||
| Sepsis, n/N (%) | 6/49 (12.2) | 5/81 (6.2) | 0.23 |
| Septic shock, n/N (%) | 1/49 (2) | 1/81 (1.2) | 0.72 |
| Source of infection | |||
| Unknown source, n/N (%) | 1/49 (2) | 9/81 (11.1) | 0.06 |
| Pneumonia, n/N (%) | 9/49 (18.4) | 20/81 (24.7) | 0.40 |
| Endocarditis/Cardiovascular, n/N (%) | 5/49 (10.2) | 0/81 (0) | <0.01 |
| Abdominal, n/N (%) | 1/49 (2) | 15/81 (18.5) | <0.01 |
| Genito-urinary, n/N (%) | 6/49 (12.2) | 13/81 (16) | 0.55 |
| Osteoarticular, n/N (%) | 3/49 (6.1) | 1/81 (1.2) | 0.12 |
| Skin and soft tissues, n/N (%) | 5/49 (10.2) | 4/81 (4.9) | 0.25 |
| Central Nervous System, n/N (%) | 1/49 (2) | 1/81 (1.2) | 0.72 |
| Bloodstream, n/N (%) | 9/49 (18.4) | 2/81 (2.5) | <0.01 |
| Other, n/N (%) | 7/49 (14.3) | 7/81 (8.6) | 0.31 |
| Missing data, n/N (%) | 4/49 (36.4) | 7/81 (63.6) | 0.92 |
| Collection of microbiology specimen, n/N (%) |
37/49 (75.5) | 36/81 (44.4) | <0.01 |