Table 4.
Adequacy of antimicrobial therapy between ASP and non-ASP units.
| Variables | ASP, N (%) | Non-ASP, N (%) | p Value |
|---|---|---|---|
| N of antimicrobial therapy prescriptions |
27 | 103 | − |
| Antibiotic therapy | |||
| Empiric therapy, N (%) | 10 (37) | 87 (84.5) | <0.01 |
| Target therapy, N (%) | 17 (63) | 16 (15.5) | <0.01 |
| Acquisition of infection | |||
| Community-acquired infection, N (%) | 16 (59.2) | 58 (56.3) | 0.78 |
| Healthcare-associated infection, N (%) | 4 (14.8) | 6 (5.8) | 0.11 |
| Nosocomial infection, N (%) | 4 (14.8) | 27 (26.2) | 0.21 |
| Unknown, N (%) | 3 (11.1) | 12 (13.1) | 0.94 |
| Severity of infection | |||
| Sepsis, N (%) | 2 (7.4) | 9 (8.7) | 0.82 |
| Septic shock, N (%) | 2 (7.4) | 0 (0) | <0.01 |
| Source of infection | |||
| Unknown source, N (%) | 0 (0) | 10 (9.7) | 0.09 |
| Pneumonia, N (%) | 6 (22.2) | 23 (22.3) | 0.99 |
| Endocarditis/Cardiovascular | 4 (14.8) | 1 (1) | <0.01 |
| Abdominal, N (%) | 2 (7.4) | 14 (13.6) | 0.38 |
| Genito-urinary, N (%) | 5 (18.5) | 14 (13.6) | 0.51 |
| Osteoarticular, N (%) | 2 (7.4) | 2 (1.9) | 0.14 |
| Skin and soft tissues, N (%) | 3 (11.1) | 6 (5.8) | 0.33 |
| Central Nervous System, N (%) | 0 (0) | 2 (1.9) | 0.46 |
| Bloodstream, N (%) | 3 (11.1) | 8 (7.8) | 0.57 |
| Other, N (%) | 1 (3.7) | 13 (12.6) | 0.18 |
| Missing data, N (%) | 1 (3.7) | 10 (9.7) | 0.31 |
| Collection of microbiology specimen, N (%) | 23 (85.2) | 50 (48.5) | <0.01 |
| Prescriptive appropriateness | |||
| Appropriate antimicrobial therapy prescription, N (%) Inappropriate antimicrobial therapy prescription, N (%) |
21 (77.7) 6 (22.3) |
34 (33) 69 (67) |
<0.01 |
| Reason for inappropriate antimicrobial therapy prescription | |||
| Antimicrobial unnecessary, n/N (%) | 0/6 (0) | 31/69 (44.9) | 0.03 |
| Antimicrobial inadequate, n/N (%) | 1/6 (16.6) | 8/69 (11.6) | 0.71 |
| Antimicrobial not recommended, n/N (%) | 4/6 (66.6) | 21/69 (30.4) | 0.07 |
| Excessive duration, n/N (%) | 0/6 (0) | 15/69 (21.7) | 0.20 |
| Inadequate dose, n/N (%) | 2/6 (33.3) | 14/69 (20.3) | 0.45 |
| Inadequate way of administration, n/N (%) | 0/6 (0) | 1/69 (1.4) | 0.77 |
| 2 reasons for inappropriate antimicrobial therapy prescription, n/N (%) | 1/6 (16.6) | 17/69 (24.6) | 0.66 |
| ≥3 reasons for inappropriate antimicrobial therapy prescription, n/N (%) | 0/6 (0) | 2/69 (2.9) | 0.67 |