Table 2.
Heparanase inhibitory activities of various samples.
| Sample | Mw (Da) |
Specific Rotation [α] |
IC50 (ng/mL) |
IC50 (nM) |
|---|---|---|---|---|
| HfFG | 47,282 | −50° | 11.4 ± 1.39 | 0.24 ± 2.94 |
| Fr-3 | 3652 a | −45° | 2346 ± 409 | 642.3 ± 112 |
| Fr-2 | 2767 | −32° | 2766 ± 381 | 999.4 ± 138 |
| Fr-1 | 1841 | −44° | 4496 ± 590 | 2440 ± 320 |
| Heparin | ~18,000 | -- | 32.3 ± 2.21 | 1.79 ± 0.12 |
| LMWH | ~4500 | -- | 300 ± 29.4 | 66.67 ± 6.53 |
a The Mw of Fr-1, Fr-2 and Fr-3 was calculated by ChemBioDraw Ultra 14.0 software based on the degree of polymerization and the composition of FucS from the integral analysis of their 1H NMR spectra, respectively.