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. 2021 Mar 18;13(3):405. doi: 10.3390/pharmaceutics13030405

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HIFU with microbubbles disrupts the BBB detected by accumulation of Evan’s blue (left panel) and Cy7-albumin (Cy7 ALB, right panel). Arrowhead, accumulation of Evan’s blue (EB) and Cy7-albumin (Cy7 ALB) in the brain of mice after HIFU.