Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 18;13(3):405. doi: 10.3390/pharmaceutics13030405

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

HIFU with microbubbles treatments permeabilize the BBB for topotecan and significantly increase the loco-regional accumulation of topotecan in the brain. (a) Representative PET images of [¹¹C] topotecan uptake in brains of control (top panels) and HIFU-treated (bottom panels) mice. Images were quantified (n = 4) and demonstrated a significant increase in [¹¹C] topotecan brain uptake after HIFU. (b) Immediately after PET imaging, the brains of all mice were dissected, imaged, and quantified with PET to confirm in vivo PET signal. PET images and quantification of [¹¹C] topotecan uptake in dissected brains confirm PET results on live mice. Arrowhead, [¹¹C] topotecan signal in the brain of mice after HIFU.