Figure 1.

Schematic representation of the different inflammasome sensor proteins. (A) Nod like receptor (NLR) proteins are formed by either a PYD (NLRP) or CARD (NLRC) domain at the N-terminal position follow by a central domain (NACHT), responsible for NLR oligomerization, and a C-terminal leucine-rich repeat domain (LRR). For NLRP1, a FIIND and CARD domain are in the C-terminal position after the LRR domain. (B) AIM2 and Pyrin are no-NLR inflammasome sensors with a PYD domain at the N-terminal. AIM2 also presents a HIN domain responsible of DNA binding. Pyrin is also formed by a central coiled BBOX domain and a C-terminal B30.2/SPRY domain.