Uncontrolled growth |
✓ |
✓ |
Ability to invade other tissues |
✓ |
✓ |
Proliferation via blood and lymphatic vessels |
✓ |
✓ |
Neoangiogenesis |
✓ |
✓ |
Lower ability to undergo apoptosis |
✓ |
✓ |
Local inflammation |
✓ |
✓ |
Increased volume of peritoneal fluid |
✓ |
✓ |
Presence of LOH (loss of heterozygosity) |
✓ |
✓ |
Mutation in genes TP53, KRAS, PTEN, PIK3CA, and ARID1A
|
✓ |
✓ |
High risk of return of the disease |
✓ |
✓ |
Oral contraceptive pills—lower risk of development of the disease |
✓ |
✓ |
Fallopian tube ligation—lower risk of development of the disease |
✓ |
✓ |
Hysterectomy—lower risk of development of the disease |
✓ |
✓ |
Multiple pregnancies—lower risk of development of the disease |
✓ |
✓ |